Fewer Steps, Greater Strides: Celebrating Breakthroughs in Sustainable Manufacturing
First join Tao Liang from Merck as he discusses the innovative approach that transformed the production of the antibody-drug conjugate (ADC) Sacituzumab tirumotecan (MK-2870). By streamlining a 20-step synthesis into just three OEB-5 handling steps derived from a natural product, they reduced the Process Mass Intensity (PMI) by ~75% and cut chromatography time by over 99%. The result: faster, greener, and more scalable access to life-saving cancer treatments.
Then Megan Cismesia of Corteva Agriscience will discuss how her team developed a route that eliminated unnecessary protecting groups and steps, avoided precious metals, and replaced hazardous reagents with greener alternatives. The result is an efficient, cost-effective process that delivers Adavelt™ active, a breakthrough fungicide protecting more than 30 crops against 20 major plant diseases, while minimizing waste and environmental impact.
Together, these achievements demonstrate how applying green chemistry principles not only improves efficiency but also expands access to vital medicines and agricultural solutions worldwide. This ACS Webinar is moderated by Christophe Allais of Pfizer and co-produced by the ACS Green Chemistry Institute Pharmaceutical Roundtable.
What You Will Learn
- How leading scientists from Merck and Corteva Agriscience transformed complex, resource-heavy processes into sustainable, scalable manufacturing routes through green chemistry innovations
- How renewable feedstocks and greener reagents can replace traditional materials, eliminating the need for precious metals and harmful chemicals
- Why investing in sustainability is not only environmentally responsible but also a driver of innovation, scalability, and cost-effectiveness in manufacturing
Event Details
- Thursday, September 18, 2025 @ 2-3:30pm ET
- Free to attend
- Slides will be available to download on the day of the webinar