Apr 30, 20202:00 PM - 3:00 PM
ACS Webinar - How Drugs Really Get Into Cells: Why Passive Bilayer Diffusion is a Myth
It is widely assumed that the majority of pharmaceutical drugs are transported into cells occurs via ‘passive diffusion’ however, the evidence for “y diffusion through the bilayer” occurring significantly in real cells is non-existent. This means that to understand drug distribution, efficacy and toxicity, we need to know the distribution of the relevant transporters and their specificities in the form of a quantitative structure-activity relationship. Armed with these we can explain the majority of drug distributions (including which cross the blood-brain barrier and why) and why drugs fail.